Residing a enormous pot of salted water to boil. In a enormous skillet, heat oil over medium-excessive. Add onion and garlic; season with salt and pepper. Cook, stirring every so incessantly, till onion softens, 3 to 4 minutes. Add pork and beef; cook dinner, breaking meat up with a spoon, till no longer crimson, 2 to three minutes. Add wine; cook dinner till evaporated, about 7 minutes. Add tomatoes, oregano, and crimson-pepper flakes; cook dinner till sauce is a diminutive thickened, 2 to three minutes.